The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …

Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy
initiation and progression,–. TET2 deficiency is known to cause a globally opened chromatin …

BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide
array of biological activities. Studies in which advanced sequencing technologies were used …

Acute myeloid leukemia (AML) with t (8; 21) or inv (16) have been recognized as unique
entities within AML and are usually reported together as core binding factor AML (CBF …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …

Histone posttranslational modifications are key regulators of chromatin-associated
processes including gene expression, DNA replication and DNA repair. Monoubiquitinated …

Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutations,
which are associated with tumors of different grade and prognosis. However, whether BAP1 …