Chondral and osteochondral lesions due to injury or other pathology commonly result in the
development of osteoarthritis, eventually leading to progressive total joint destruction …

Background: The surfaces of the bones in the knee are covered with articular cartilage, a
rubber-like substance that is very smooth, allowing frictionless movement in the joint and …

Fresh osteochondral allograft (OCA) transplantation has been used to manage a wide
spectrum of chondral and osteochondral knee disorders. Basic science and clinical studies …

There is currently widespread interest within the biomaterial field to locally deliver
biomolecules for bone and cartilage regeneration. Substantial work to date has focused on …

Introduction. We investigated the use of autologous bone marrow concentrate (BMC) with
and without an adipose graft, for treatment of knee osteoarthritis (OA). Methods. Treatment …

The process of cartilage destruction in the diarthrodial joint is progressive and irreversible.
This destruction is extremely difficult to manage and frustrates researchers, clinicians, and …

Many attempts have been made to repair articular cartilage defects, including mesenchymal
stem cell (MSC)-based tissue engineering strategies. Although this approach shows …

Articular cartilage (AC), which covers the ends of bones in joints, particularly the knee joints,
provides a robust interface to maintain frictionless movement during daily life due to its …

Purpose Regenerative techniques for articular cartilage lesions demonstrated
heterogeneous clinical results. Several factors may influence the outcome, with sex being …

The technique of osteochondral allograft (OCA) transplantation has been used to treat a
wide spectrum of cartilage deficiencies in the knee. Its use has been supported by basic …