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Dissecting metastasis using preclinical models and methods
Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …
deaths. However, our understanding of the metastatic process, and thus our ability to …
RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an
essential role in regulation of tumor growth and metastasis. The cellular and molecular …
essential role in regulation of tumor growth and metastasis. The cellular and molecular …
RNA-based therapies: A cog in the wheel of lung cancer defense
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …
Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery
Y Zhang, X Tian, Z Wang, H Wang, F Liu… - Frontiers in Molecular …, 2023 - frontiersin.org
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands
and creates specific structures based on the complementary base pairing principle. These …
and creates specific structures based on the complementary base pairing principle. These …
Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis
Metastatic breast cancer is a leading health burden worldwide. Previous studies have
shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy …
shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy …
Insights on the biomarker potential of exosomal non-coding RNAs in colorectal cancer: an in silico characterization of related exosomal lncRNA/circRNA–miRNA …
Colorectal cancer (CRC) is one of the most common cancer types, ranking third after lung
and breast cancers. As such, it demands special attention for better characterization, which …
and breast cancers. As such, it demands special attention for better characterization, which …
M2‐Macrophage‐Derived Exosomes Promote Meningioma Progression through TGF‐β Signaling Pathway
XH Fu, JP Li, XY Li, Y Tan, M Zhao… - Journal of …, 2022 - Wiley Online Library
Tumor‐associated macrophages (TAMs) have been shown to be an essential component of
the tumor microenvironment and facilitate the proliferation and invasion of a variety of …
the tumor microenvironment and facilitate the proliferation and invasion of a variety of …
LINC00665 knockdown confers sensitivity in irradiated non-small cell lung cancer cells through the miR-582-5p/UCHL3/AhR axis
LM Xu, YJ Yuan, H Yu, S Wang, P Wang - Journal of Translational …, 2022 - Springer
Background The resistance to radiotherapy remains a major obstacle that limits the efficacy
of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the …
of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the …
Targeting ADAR1 with a small molecule for the treatment of prostate cancer
X Wang, J Li, Y Zhu, H Shen, J Ding, T Zeng, W Min… - Nature Cancer, 2025 - nature.com
Despite the initial response to androgen signaling therapy, most cases of prostate cancer
(PCa) eventually relapse and remain incurable. The specific function of ADAR1 that governs …
(PCa) eventually relapse and remain incurable. The specific function of ADAR1 that governs …
SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer
SND1 and MTDH are known to promote cancer and therapy resistance, but their
mechanisms and interactions with other oncogenes remain unclear. Here, we show that …
mechanisms and interactions with other oncogenes remain unclear. Here, we show that …