Dissecting metastasis using preclinical models and methods

JD Hebert, JW Neal, MM Winslow - Nature Reviews Cancer, 2023 - nature.com
Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics

PR Pandey, KH Young, D Kumar, N Jain - Molecular cancer, 2022 - Springer
Accumulating research suggests that the tumor immune microenvironment (TIME) plays an
essential role in regulation of tumor growth and metastasis. The cellular and molecular …

RNA-based therapies: A cog in the wheel of lung cancer defense

P Khan, JA Siddiqui, I Lakshmanan, AK Ganti, R Salgia… - Molecular cancer, 2021 - Springer
Lung cancer (LC) is a heterogeneous disease consisting mainly of two subtypes, non-small
cell lung cancer (NSCLC) and small cell lung cancer (SCLC), and remains the leading …

Advanced applications of DNA nanostructures dominated by DNA origami in antitumor drug delivery

Y Zhang, X Tian, Z Wang, H Wang, F Liu… - Frontiers in Molecular …, 2023 - frontiersin.org
DNA origami is a cutting-edge DNA self-assembly technique that neatly folds DNA strands
and creates specific structures based on the complementary base pairing principle. These …

Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis

M Shen, Y Wei, H Kim, L Wan, YZ Jiang, X Hang… - Nature cancer, 2022 - nature.com
Metastatic breast cancer is a leading health burden worldwide. Previous studies have
shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy …

Insights on the biomarker potential of exosomal non-coding RNAs in colorectal cancer: an in silico characterization of related exosomal lncRNA/circRNA–miRNA …

M Mezher, S Abdallah, O Ashekyan, AA Shoukari… - Cells, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most common cancer types, ranking third after lung
and breast cancers. As such, it demands special attention for better characterization, which …

M2‐Macrophage‐Derived Exosomes Promote Meningioma Progression through TGF‐β Signaling Pathway

XH Fu, JP Li, XY Li, Y Tan, M Zhao… - Journal of …, 2022 - Wiley Online Library
Tumor‐associated macrophages (TAMs) have been shown to be an essential component of
the tumor microenvironment and facilitate the proliferation and invasion of a variety of …

LINC00665 knockdown confers sensitivity in irradiated non-small cell lung cancer cells through the miR-582-5p/UCHL3/AhR axis

LM Xu, YJ Yuan, H Yu, S Wang, P Wang - Journal of Translational …, 2022 - Springer
Background The resistance to radiotherapy remains a major obstacle that limits the efficacy
of radiotherapy in non-small cell lung cancer (NSCLC). This study aims to illustrate the …

Targeting ADAR1 with a small molecule for the treatment of prostate cancer

X Wang, J Li, Y Zhu, H Shen, J Ding, T Zeng, W Min… - Nature Cancer, 2025 - nature.com
Despite the initial response to androgen signaling therapy, most cases of prostate cancer
(PCa) eventually relapse and remain incurable. The specific function of ADAR1 that governs …

SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer

SY Liao, D Rudoy, SB Frank, LT Phan… - Nature …, 2023 - nature.com
SND1 and MTDH are known to promote cancer and therapy resistance, but their
mechanisms and interactions with other oncogenes remain unclear. Here, we show that …