Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …

Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are
known to induce oxidative stress. In the context of cancer development, cancer cells adeptly …

RRx-001 is a shape shifting small molecule with Fast Track designation for the prevention/
amelioration of chemoradiation-induced severe oral mucositis (SOM) in newly diagnosed …

After extensive screening of aerospace compounds in an effort to source a novel anticancer
agent, RRx-001, a first-in-class dinitroazetidine small molecule, was selected for …

Currently, antitumor drugs show limited clinical outcomes, mainly due to adaptive resistance.
Clinical evidence has highlighted the importance of the tumor microenvironment (TME) and …

Low level nitric oxide (NO) produced by inducible NO synthase (iNOS) in many malignant
tumors is known to play a key role in the survival and proliferation of tumor cells. NO can …

Abstract Background Adaptive designs (ADs) are intended to make clinical trials more
flexible, offering efficiency and potentially cost-saving benefits. Despite a large number of …

The human epidermal growth factor receptor (HER) family consists of four members,
activated by two families of ligands. They are known for mediating cell–cell interactions in …

Radiotherapy remains a key treatment modality for both primary and metastatic brain tumors.
Significant technological advances in precision radiotherapy, such as stereotactic …

Background Radiation therapy (RT) is the cornerstone of management of malignant brain
tumors, but its efficacy is limited in hypoxic tumors. Although numerous radiosensitizer …