A complex systems approach to aging biology
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …
aging biology research is now moving toward integration of these parts, attempting to …
[HTML][HTML] Protein synthesis and quality control in aging
Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …
Distinct longevity mechanisms across and within species and their association with aging
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …
[HTML][HTML] CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence
L Crozier, R Foy, R Adib, A Kar, JA Holt, AU Pareri… - Molecular cell, 2023 - cell.com
Abnormal increases in cell size are associated with senescence and cell cycle exit. The
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …
mechanisms by which overgrowth primes cells to withdraw from the cell cycle remain …
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation
E Kelmer Sacramento, JM Kirkpatrick… - Molecular systems …, 2020 - embopress.org
A progressive loss of protein homeostasis is characteristic of aging and a driver of
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
neurodegeneration. To investigate this process quantitatively, we characterized proteome …
The nuclear pore complex: birth, life, and death of a cellular behemoth
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
Proteostasis collapse is a driver of cell aging and death
What molecular processes drive cell aging and death? Here, we model how proteostasis—
ie, the folding, chaperoning, and maintenance of protein function—collapses with age from …
ie, the folding, chaperoning, and maintenance of protein function—collapses with age from …
Gene expression hallmarks of cellular ageing
S Frenk, J Houseley - Biogerontology, 2018 - Springer
Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …
[HTML][HTML] Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality
SC Schüler, JM Kirkpatrick, M Schmidt, D Santinha… - Cell reports, 2021 - cell.com
During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …
The evolution of the hallmarks of aging
M Lemoine - Frontiers in Genetics, 2021 - frontiersin.org
The evolutionary theory of aging has set the foundations for a comprehensive understanding
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …
of aging. The biology of aging has listed and described the “hallmarks of aging,” ie, cellular …