Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Background The translocator protein (18 kDa)(TSPO) is a mitochondrial protein expressed
on reactive glial cells and a biomarker for gliosis in the brain. TSPO ligands have been …

Steroidogenesis begins with cholesterol transfer into mitochondria through the
transduceosome, a complex composed of cytosolic proteins that include steroidogenesis …

Abstract The Translocator Protein 18 kDa (TSPO) has been discovered in 1977 as an
alternative binding site for the benzodiazepine diazepam. It is an evolutionary well …

In the past decades considerable evidence has emerged that so-called neuroactive steroids
do not only act as transcriptional factors in the regulation of gene expression but may also …

Translocator protein (TSPO), a 18 kDa protein found in the outer mitochondrial membrane,
has historically been associated with the transport of cholesterol in highly steroidogenic …

Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor
prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical …

The 18 kDa translocator protein (TSPO) is predominantly located in the mitochondrial outer
membrane, playing an important role in steroidogenesis, inflammation, survival, and cell …

The translocator protein 18kDa (TSPO) is expressed in the outer mitochondrial membrane
and is implicated in several functions, including cholesterol transport and steroidogenesis …