GABAkines, or positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors,
are used for the treatment of anxiety, epilepsy, sleep, and other disorders. The search for …

Drug abuse is associated with a variety of neurological complications. The use of certain
recreational drugs shows a marked temporal association with the onset of both …

Cannabidiol (CBD), a major non-psychotomimetic constituent of Cannabis sativa, has
therapeutic potential for certain psychiatric and neurological disorders. Studies in laboratory …

Patients with acute cocaine poisoning present with life-threatening symptoms involving
several organ systems. While the effects of cocaine are myriad, they are the result of a …

Background The anesthetic drug ketamine (KT) has been reported to be an abused drug
and fatal cases have been observed in polydrug users. In the present study, considering the …

Seizures associated with cocaine intoxication are serious clinical problem requiring
immediate and adequate treatment, however their mechanism has not been fully elucidated …

Selective serotonin reuptake inhibitors (SSRIs) can reduce seizure frequency in humans, but
no large‐scale clinical trials have been done to test the utility of SSRIs as potential …

Rationale: It has been hypothesized that low-affinity, uncompetitive N-methyl-d-aspartate
(NMDA) antagonists may have therapeutic efficacy (eg, in epilepsy, stroke, drug …

Neuroactive steroids demonstrate pharmacological actions that have relevance for a host of
neurological and psychiatric disorders. They offer protection against seizures in a range of …

The present study characterized the effects of withdrawal from cocaine on the expression of
NMDA receptor subunits (NR1, NR2B) and neuronal nitric oxide synthase. FosB induction …