Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Abstract Poly (2-oxazoline) s have been investigated for decades as biomaterials.
Pioneering early work suggested that hydrophilic poly (2-oxazoline) s are comparable to …

Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

Purpose. Low molecular weight branched polyethylenimine (LMW-PEI) was synthesized
and studied as a DNA carrier for gene delivery with regard to physico-chemical properties …

Since the first published examination of poly (ethylenimine)(PEI) as a gene delivery vehicle,
there has been a flurry of research aimed at this polycation and its role in gene therapy …

Abstract Poly (ethylenimine)(PEI) samples of various molecular weights and pHs were used
to transfect endothelial cells to achieve levels of gene expression for comparison. PEIs with …

We investigated the in vitro and in vivo properties of DNA/transferrin–polyethylenimine (800
kDa) complexes before and after covalent coupling of poly (ethylene glycol)(PEG). Upon …

We investigated the effects of inhibitors of clathrin-mediated endocytosis (chlorpromazine
and K+ depletion) and of caveolae-mediated uptake (filipin and genistein) on internalization …

Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and
safely carrythe gene into the nucleus of the desired cells. A series of chemically …