PARP and PARG inhibitors in cancer treatment
D Slade - Genes & development, 2020 - genesdev.cshlp.org
Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …
genomic instability through radiotherapy and chemotherapy has been a powerful but …
Methods favoring homology-directed repair choice in response to CRISPR/Cas9 induced-double strand breaks
H Yang, S Ren, S Yu, H Pan, T Li, S Ge… - International journal of …, 2020 - mdpi.com
Precise gene editing is—or will soon be—in clinical use for several diseases, and more
applications are under development. The programmable nuclease Cas9, directed by a …
applications are under development. The programmable nuclease Cas9, directed by a …
The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
Repair pathway choices and consequences at the double-strand break
DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity.
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
Failure to repair a DSB has deleterious consequences, including genomic instability and cell …
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP
inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by …
inhibitors (PARPi). We show that acquisition of PARPi-resistance is accompanied by …
[HTML][HTML] RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
ABSTRACT Background BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired
homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents …
homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents …
How cells ensure correct repair of DNA double-strand breaks
J Her, SF Bunting - Journal of Biological Chemistry, 2018 - ASBMB
DNA double-strand breaks (DSBs) arise regularly in cells and when left unrepaired cause
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
senescence or cell death. Homologous recombination (HR) and nonhomologous end …
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells
DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
Mechanism and regulation of DNA end resection in eukaryotes
LS Symington - Critical reviews in biochemistry and molecular …, 2016 - Taylor & Francis
The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …