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[HTML][HTML] Nanotechnologies for the delivery of biologicals: Historical perspective and current landscape
Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene
generating a great hope due to their outstanding specificity and potency. However, given …
generating a great hope due to their outstanding specificity and potency. However, given …
Functional antibody delivery: Advances in cellular manipulation
KC Koch, GN Tew - Advanced Drug Delivery Reviews, 2023 - Elsevier
The current therapeutic antibody market in the US consists of 100 antibody-based products
and their market value is expected to explode beyond $300 billion by 2025. These therapies …
and their market value is expected to explode beyond $300 billion by 2025. These therapies …
Improved delivery of Mcl-1 and survivin siRNA combination in breast cancer cells with additive siRNA complexes
T Santadkha, W Skolpap, R KC, A Ansari… - Investigational New …, 2022 - Springer
This study aimed at investigating the influence of commercial transfection reagents (Prime-
Fect, Leu-Fect A, and Leu-Fect C) complexed with different siRNAs (CDC20, HSP90, Mcl-1 …
Fect, Leu-Fect A, and Leu-Fect C) complexed with different siRNAs (CDC20, HSP90, Mcl-1 …
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury
D Köhler, V Leiss, L Beichert, S Killinger… - Basic Research in …, 2024 - Springer
Neutrophils are not only involved in immune defense against infection but also contribute to
the exacerbation of tissue damage after ischemia and reperfusion. We have previously …
the exacerbation of tissue damage after ischemia and reperfusion. We have previously …
Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: Diamond cuts diamond
VV Oberemok, OA Andreeva, KV Laikova… - Inflammation …, 2022 - Springer
The coronavirus pandemic has starkly demonstrated the need to create highly effective
vaccines against various viral diseases. The emerging new platforms for vaccine creation …
vaccines against various viral diseases. The emerging new platforms for vaccine creation …
Development of pepper vein banding virus chimeric virus-like particles for potential diagnostic and therapeutic applications
P Sabharwal, C Sushmitha, CK Amritha, U Natraj… - Archives of …, 2020 - Springer
Monoclonal antibodies have attracted wide attention in therapeutics owing to their high
efficacy, low toxicity, and specific targeting. However, antibodies cannot cross the cell …
efficacy, low toxicity, and specific targeting. However, antibodies cannot cross the cell …
[PDF][PDF] Predictive modelling and simulation for taming the chance and luck in biologics drug discovery.
A Sepp - Proceedings of the Estonian Academy of Sciences, 2023 - kirj.ee
Three Pillars of Survival paradigm in the pharmaceutical drug discovery stipulates that a
drug candidate is more likely to reach Phase III if it meets the following criteria: 1) it reaches …
drug candidate is more likely to reach Phase III if it meets the following criteria: 1) it reaches …
[ЦИТИРОВАНИЕ][C] Targeting Gα
D Köhler, V Leiss, L Beichert, S Killinger, D Grothe… - 2024