Transcription-coupled supercoiling of DNA is a key factor in chromosome compaction and
the regulation of genetic processes in all domains of life. It has become common knowledge …

Chromosome inheritance depends on centromeres, epigenetically specified regions of
chromosomes. While conventional human centromeres are known to be built of long tandem …

Prokaryotic transcription was extensively studied over the last half-century. A great deal of
data has been accumulated regarding the control of gene expression by transcription factors …

We have developed a fabrication methodology for label-free optical trap** of individual
nanobeads and proteins in inverted-bowtie-shaped plasmonic gold nanopores. Arrays of …

It is unclear how gene order within the chromosome influences genome evolution. Bacteria
cluster transcription and translation genes close to the replication origin (oriC). In Vibrio …

Type III and type VI secretion systems (T3/T6SS) are encoded in horizontally acquired
genomic islands (GIs) that play crucial roles in evolution and virulence in bacterial …

Living systems are capable on the one hand of eliciting a coordinated response to changing
environments (also known as adaptation), and on the other hand, they are capable of …

Chromosome structure and function is studied using various cell-based methods as well as
with a range of in vitro single-molecule techniques on short DNA substrates. Here, we …

In spite of the nanoscale and single-molecule insights into nucleoid associated proteins
(NAPs), their role in modulating the mesoscale viscoelasticity of entangled DNA has been …

The transcription of genes and engineered circuits can deeply vary when inserted into
different genomic loci. This unpredictable performance, termed context sensitivity …