Human microglial state dynamics in Alzheimer's disease progression
N Sun, MB Victor, YP Park, X ** in the adult mouse CNS using hierarchical clustering on principal components reveals regional heterogeneity but no sexual dimorphism
HRJ van Weering, TW Nijboer, ML Brummer… - Glia, 2023 - Wiley Online Library
Microglia are the resident macrophages of the central nervous system (CNS) and play a
pivotal role in immune surveillance and CNS homeostasis. Morphological transitions in …
pivotal role in immune surveillance and CNS homeostasis. Morphological transitions in …
Innovations advancing our understanding of microglia in Alzheimer's disease: from in vitro to in vivo models
Microglia have been implicated in Alzheimer's disease (AD) pathogenesis through the
identification of risk factor genes that are specifically or predominantly expressed in this cell …
identification of risk factor genes that are specifically or predominantly expressed in this cell …
Development of a high-throughput pipeline to characterize microglia morphological states at a single-cell resolution
As rapid responders to their environments, microglia engage in functions that are mirrored
by their cellular morphology. Microglia are classically thought to exhibit a ramified …
by their cellular morphology. Microglia are classically thought to exhibit a ramified …
Online conversion of reconstructed neural morphologies into standardized SWC format
Digital reconstructions provide an accurate and reliable way to store, share, model, quantify,
and analyze neural morphology. Continuous advances in cellular labeling, tissue …
and analyze neural morphology. Continuous advances in cellular labeling, tissue …
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease
Background Sex differences in the brain may play an important role in sex-differential
prevalence of neuropsychiatric conditions. Methods In order to understand the …
prevalence of neuropsychiatric conditions. Methods In order to understand the …
[HTML][HTML] Microglial function interacts with the environment to affect sex-specific depression risk
There is a two-fold higher incidence of depression in females compared to men with recent
studies suggesting a role for microglia in conferring this sex-dependent depression risk. In …
studies suggesting a role for microglia in conferring this sex-dependent depression risk. In …