Of all the gynecologic tumors, ovarian cancer (OC) is known to be the deadliest. Advanced‐
stages of OC are linked with high morbidity and low survival rates despite the immense …

Immunotherapy has revolutionized cancer therapy, largely attributed to the success of
immune-checkpoint blockade. However, there are subsets of patients across multiple …

Primary tumors may create the premetastatic niche in secondary organs for subsequent
metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles …

Ongoing research into the application of nanotechnology for cancer treatment and diagnosis
has demonstrated its advantages within contemporary oncology as well as its intrinsic …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs.
Canine mammary cancer (CMC) represents 50% of CMTs, and besides surgery, which is the …

Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer, accounting for
approximately 15% among all lung cancers. Despite the ability of chemotherapy, the first …

Colorectal cancer (CRC) is one of the most common cancers worldwide. Current therapies
such as surgery, chemotherapy, and radiotherapy encounter obstacles in preventing …

viii everybody who contributed to the first edition. As always, I have to thank my wife and
family for encouragement and support (as well as patience…). I hope you will find this book …

Chimeric antigen receptor T cells (CAR-Ts) are promising cancer therapeutics. However,
since cancer cells can lose the CAR-targeted antigen and avoid destruction, targeting …