Targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications

BJB Nelson, JD Andersson, F Wuest - Pharmaceutics, 2020 - mdpi.com
This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …

Radiolabeled nanomaterials for biomedical applications: radiopharmacy in the era of nanotechnology

MSO Pijeira, H Viltres, J Kozempel, M Sakmár… - EJNMMI …, 2022 - Springer
Background Recent advances in nanotechnology have offered new hope for cancer
detection, prevention, and treatment. Nanomedicine, a term for the application of …

Radiometals in Imaging and Therapy: Highlighting Two Decades of Research

S Sharma, MK Pandey - Pharmaceuticals, 2023 - mdpi.com
The present article highlights the important progress made in the last two decades in the
fields of molecular imaging and radionuclide therapy. Advancements in radiometal-based …

Alpha dose modeling in diffusing alpha‐emitters radiation therapy—Part I: single‐seed calculations in one and two dimensions

G Heger, A Roy, M Dumančić, L Arazi - Medical Physics, 2023 - Wiley Online Library
Abstract Background Diffusing alpha‐emitters Radiation Therapy (“DaRT”) is a new method,
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …

Alpha dose modeling in diffusing alpha‐emitters radiation therapy. Part II: Lattice studies

G Heger, M Dumančić, A Roy, L Arazi - Medical Physics, 2023 - Wiley Online Library
Background Diffusing alpha‐emitters radiation therapy (“DaRT”) is a new method, presently
in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies on …

Atomic nanogenerators in targeted alpha therapies: Curie's legacy in modern cancer management

M Roscher, G Bakos, M Benešová - Pharmaceuticals, 2020 - mdpi.com
Atomic in vivo nanogenerators such as actinium-225, thorium-227, and radium-223 are of
increasing interest and importance in the treatment of patients with metastatic cancer …

Diffusing alpha-emitters radiation therapy in combination with temozolomide or bevacizumab in human glioblastoma multiforme xenografts

Y Nishri, M Vatarescu, I Luz, L Epstein… - Frontiers in …, 2022 - frontiersin.org
Glioblastoma multiforme (GBM) is at present an incurable disease with a 5-year survival rate
of 5.5%, despite improvements in treatment modalities such as surgery, radiation therapy …

Diffusing alpha-emitters radiation therapy: approximate modeling of the macroscopic alpha particle dose of a point source

L Arazi - Physics in Medicine & Biology, 2020 - iopscience.iop.org
Diffusing alpha-emitters radiation therapy ('DaRT') is a new cancer-treatment modality,
which enables treating solid tumors by alpha particles. The treatment utilizes implantable …

RIG-1-like receptor activation synergizes with intratumoral alpha radiation to induce pancreatic tumor rejection, triple-negative breast metastases clearance, and …

V Domankevich, M Efrati, M Schmidt, E Glikson… - Frontiers in …, 2020 - frontiersin.org
Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated
seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside …