Hepatitis C virus (HCV) remains a significant global health challenge. Approximately 50
million people were living with chronic hepatitis C based on the World Health Organization …

Background & Aims Liver cancer is a common malignant neoplasm worldwide. The
etiologies for liver cancer are diverse and the incidence trends of liver cancer caused by …

RNA viruses have evolved elaborate strategies to protect their genomes, including 5′
cap**. However, until now no RNA 5′ cap has been identified for hepatitis C virus,(HCV) …

Hepatitis C virus (HCV) preferentially replicates in the human liver and frequently causes
chronic infection, often leading to cirrhosis and liver cancer. HCV is an enveloped virus …

While viral replication processes are largely understood, comparably little is known on
cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5′-triphosphate (PPP-) …

Hepatitis C virus (HCV) requires two cellular factors, microRNA-122 (miR-122) and poly (C)
binding protein 2 (PCBP2), for optimal replication. These host factors compete for binding to …

Background Liver cancer is a commonly diagnosed malignancy in China. The etiologies of
liver cancer are widely known, although studies on temporal trends in liver cancer caused by …

Abstract microRNAs (miRNAs) form regulatory networks in metazoans. Viruses engage
miRNA networks in numerous ways, with Flaviviridae members exploiting direct interactions …

Seventy percent of people infected with hepatitis C virus (HCV) will suffer chronic infection,
putting them at risk for liver disease, including hepatocellular carcinoma. The full range of …

Chronic liver disease (CLD) represents a global health problem, accounting for the heavy
burden of disability and increased health care utilization. Epigenome alterations play an …