Dilated cardiomyopathy: causes, mechanisms, and current and future treatment approaches
Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …
Phospholamban R14del disease: The past, the present and the future
E Vafiadaki, PC Glijnis, PA Doevendans… - Frontiers in …, 2023 - frontiersin.org
Arrhythmogenic cardiomyopathy affects significant number of patients worldwide and is
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …
characterized by life-threatening ventricular arrhythmias and sudden cardiac death …
Aberrant PLN-R14del Protein Interactions Intensify SERCA2a Inhibition, Driving Impaired Ca2+ Handling and Arrhythmogenesis
E Vafiadaki, K Haghighi, DA Arvanitis… - International Journal of …, 2022 - mdpi.com
Phospholamban (PLN), a key modulator of Ca2+-homeostasis, inhibits sarcoplasmic
reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human …
reticulum (SR) calcium-ATPase (SERCA2a) and regulates cardiac contractility. The human …
Bromuconazole exposure induces cardiotoxicity and lipid transport disorder in larval zebrafish
Z Qin, W Wang, Y Weng, Z Bao, G Yang… - … and Physiology Part C …, 2022 - Elsevier
Bromuconazole (BRO), as one of the typical triazole fungicides, has not been reported on its
effects on aquatic organisms. In this study, zebrafish embryos were used as experimental …
effects on aquatic organisms. In this study, zebrafish embryos were used as experimental …
RBPMS2 is a myocardial-enriched splicing regulator required for cardiac function
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …
transcriptional regulation of gene expression. Numerous RBPs have been implicated in …
Modeling human cardiac arrhythmias: insights from zebrafish
Cardiac arrhythmia, or irregular heart rhythm, is associated with morbidity and mortality and
is described as one of the most important future public health challenges. Therefore …
is described as one of the most important future public health challenges. Therefore …
[HTML][HTML] Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish
The phospholamban mutation Arg 9 to Cys (R9C) has been found to cause a dilated
cardiomyopathy in humans and in transgenic mice, with ventricular dilation and premature …
cardiomyopathy in humans and in transgenic mice, with ventricular dilation and premature …
Early consequences of the phospholamban mutation PLN‐R14del+/− in a transgenic mouse model
C Maniezzi, M Eskandr, C Florindi, M Ferrandi… - Acta …, 2024 - Wiley Online Library
Aims The heterozygous phospholamban (PLN) mutation R14del (PLN R14del+/−) is
associated with a severe arrhythmogenic cardiomyopathy (ACM) develo** in the …
associated with a severe arrhythmogenic cardiomyopathy (ACM) develo** in the …
[HTML][HTML] Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility
X Jiang, OT Ly, H Chen, Z Zhang, BA Ibarra, MA Pavel… - Iscience, 2024 - cell.com
Developmental causes of the most common arrhythmia, atrial fibrillation (AF), are poorly
defined, with compensation potentially masking arrhythmic risk. Here, we delete 9 amino …
defined, with compensation potentially masking arrhythmic risk. Here, we delete 9 amino …
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
FM Bosada, K van Duijvenboden, AE Giovou… - Elife, 2023 - elifesciences.org
Heart development and rhythm control are highly Tbx5 dosage-sensitive. TBX5
haploinsufficiency causes congenital conduction disorders, whereas increased expression …
haploinsufficiency causes congenital conduction disorders, whereas increased expression …