The pleiotropic effects of creatine (Cr) are based mostly on the functions of the enzyme
creatine kinase (CK) and its high-energy product phosphocreatine (PCr). Multidisciplinary …

Calcium is an important signaling molecule involved in the regulation of many cellular
functions. The large free energy in the Ca2+ ion membrane gradients makes Ca2+ signaling …

Ca2+ plays a crucial role in connecting membrane excitability with contraction in
myocardium. The hallmark features of heart failure are mechanical dysfunction and …

As one of the highest energy consumer organ in mammals, the heart has to be provided with
a high amount of energy as soon as its first beats in utero. During the development of this …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …

AMP-activated protein kinase (AMPK) is a heterotrimeric protein kinase that is crucial for
cellular energy homeostasis of eukaryotic cells and organisms. Here we report on the …

High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

Respiratory variation in the inferior vena cava (ΔIVC) has been extensively studied with
respect to its value in predicting fluid responsiveness, but the results are conflicting. This …

Creatine kinase catalyses the reversible transphosphorylation of creatine by ATP. In the cell,
creatine kinase isoenzymes are specifically localized at strategic sites of ATP consumption …