Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

[HTML][HTML] Nootropics as cognitive enhancers: types, dosage and side effects of smart drugs

M Malík, P Tlustoš - Nutrients, 2022 - mdpi.com
Nootropics, also known as “smart drugs” are a diverse group of medicinal substances whose
action improves human thinking, learning, and memory, especially in cases where these …

Ferroptosis and its role in diverse brain diseases

A Weiland, Y Wang, W Wu, X Lan, X Han, Q Li… - Molecular …, 2019 - Springer
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

E Llabani, RW Hicklin, HY Lee, SE Motika… - Nature …, 2019 - nature.com
The chemical diversification of natural products provides a robust and general method for
the creation of stereochemically rich and structurally diverse small molecules. The resulting …

Oxytosis/ferroptosis—(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system

J Lewerenz, G Ates, A Methner, M Conrad… - Frontiers in …, 2018 - frontiersin.org
Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

The chemical biology of ferroptosis in the central nervous system

RR Ratan - Cell chemical biology, 2020 - cell.com
Over the past five decades, thanatology has come to include the study of how individual
cells in our bodies die appropriately and inappropriately in response to physiological and …

Oxidative stress, glutamate, and neurodegenerative disorders

JT Coyle, P Puttfarcken - Science, 1993 - science.org
There is an increasing amount of experimental evidence that oxidative stress is a causal, or
at least an ancillary, factor in the neuropathology of several adult neurodegenerative …

Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria

Y Kimura, YI Goto, H Kimura - Antioxidants & redox signaling, 2010 - liebertpub.com
Hydrogen sulfide (H2S) is a synaptic modulator as well as a neuroprotectant in the brain. We
recently showed that H2S protects neurons from oxidative stress by increasing the levels of …

Hydrogen sulfide protects neurons from oxidative stress

Y Kimura, H Kimura - The FASEB journal, 2004 - Wiley Online Library
ABSTRACT Hydrogen sulfide (H2S), which is a well‐known toxic gas, is found in relatively
high concentrations in the brain. Although a neuromodulatory role of H2S has been …

Natural compounds as medical strategies in the prevention and treatment of psychiatric disorders seen in neurological diseases

E Küpeli Akkol, I Tatlı Çankaya… - Frontiers in …, 2021 - frontiersin.org
Psychiatric disorders are frequently encountered in many neurological disorders, such as
Alzheimer's and Parkinson diseases along with epilepsy, migraine, essential tremors, and …