The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …

Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …

Abstract Background In the six Southeast Asian countries that make up the Greater Mekong
Subregion, Plasmodium falciparum has developed resistance to derivatives of artemisinin …

Artemisinin resistance (delayed P. falciparum clearance following artemisinin-based
combination therapy), is widespread across Southeast Asia but to date has not been …

Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …

The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …

Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …

Background A multidrug-resistant co-lineage of Plasmodium falciparum malaria, named
KEL1/PLA1, spread across Cambodia in 2008–13, causing high rates of treatment failure …

The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium
falciparum malaria parasites has led to widespread treatment failures across Southeast …