Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia
dysfunction that form an important and rapidly expanding disease category. Ciliopathies are …

The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent
cells, the primary cilium insulates itself from contiguous dynamic membrane processes on …

Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …

Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

Increased nuclear accumulation of β-catenin, a mediator of canonical Wnt signaling, is found
in numerous tumors and is frequently associated with tumor progression and metastasis …

Primary cilia were the largely neglected nonmotile counterparts of their better-known cousin,
the motile cilia. For years these nonmotile cilia were considered evolutionary remnants of …

Joubert syndrome is a congenital cerebellar ataxia with autosomal recessive or X-linked
inheritance, the diagnostic hallmark of which is a unique cerebellar and brainstem …