Erectile dysfunction and diabetes: A melting pot of circumstances and treatments
Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of
blood glucose, is among the most common chronic diseases. The incidence and prevalence …
blood glucose, is among the most common chronic diseases. The incidence and prevalence …
Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions
SH Francis, MA Blount, JD Corbin - Physiological reviews, 2011 - journals.physiology.org
The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™),
vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile …
vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile …
Sexual dysfunction and cardiac risk (the Second Princeton Consensus Conference)
JB Kostis, G Jackson, R Rosen… - The American journal of …, 2005 - Elsevier
Recent studies have highlighted the relation between erectile dysfunction (ED) and
cardiovascular disease. In particular, the role of endothelial dysfunction and nitric oxide in …
cardiovascular disease. In particular, the role of endothelial dysfunction and nitric oxide in …
Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: pathophysiology and mechanism (s) of action
Background The PDE5 inhibitor tadalafil is investigation for the treatment of lower urinary
tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Several clinical …
tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Several clinical …
Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links
C Vlachopoulos, K Rokkas, N Ioakeimidis… - European urology, 2007 - Elsevier
OBJECTIVE: Erectile dysfunction (ED) may be the early clinical manifestation of a
generalized vascular disease and carries an independent risk for cardiovascular events …
generalized vascular disease and carries an independent risk for cardiovascular events …
Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease
Aims Erectile dysfunction (ED) confers an independent cardiovascular risk. We investigated
the role of low-grade inflammation and endothelial dysfunction in ED patients with or without …
the role of low-grade inflammation and endothelial dysfunction in ED patients with or without …
Oral phosphodiesterase-5 inhibitors and hormonal treatments for erectile dysfunction: a systematic review and meta-analysis
A Tsertsvadze, HA Fink, F Yazdi… - Annals of internal …, 2009 - acpjournals.org
Background: Erectile dysfunction (ED) is a common male sexual disorder. The relative
benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal …
benefits and harms of pharmacologic therapies for ED, as well as the value of hormonal …
Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized …
BACKGROUND: Erectile dysfunction (ED) is a chronic disease; however, therapy is currently
administered as needed with oral phosphodiesterase 5 (PDE5) inhibitors like tadalafil …
administered as needed with oral phosphodiesterase 5 (PDE5) inhibitors like tadalafil …
Erectile dysfunction and diabetes: a review of the current evidence-based medicine and a synthesis of the main available therapies
V Phé, M Rouprêt - Diabetes & metabolism, 2012 - Elsevier
AIM: This review aimed to provide an update of the epidemiology, pathophysiology and
management of erectile dysfunction (ED) in diabetes patients. METHODS: Data on the …
management of erectile dysfunction (ED) in diabetes patients. METHODS: Data on the …