Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …

All steps of cryogenic electron-microscopy (cryo-EM) workflows have rapidly evolved over
the last decade. Advances in both single-particle analysis (SPA) cryo-EM and cryo-electron …

Traditionally, structural biologists approach the complexity of cellular proteomes in a
reductionist manner. Proteomes are fractionated, their molecular components purified and …

Cryo-electron tomography (cryo-ET) has become a powerful approach to study the high-
resolution structure of cellular macromolecular machines in situ. However, the current …

Cryo-correlative light and electron microscopy (CLEM) is a technique that uses the
spatiotemporal cues from fluorescence light microscopy (FLM) to investigate the high …

Cryo-electron microscopy (CryoEM) has superseded X-ray crystallography and NMR to
emerge as a popular and effective tool for structure determination in recent times. It has …

Trypanosoma brucei is one of only a few unicellular pathogens that thrives extracellularly in
the vertebrate host. Consequently, the cell surface plays a critical role in both immune …

Abstract Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …

Retroviruses have a very complex and tightly controlled life cycle which has been studied
intensely for decades. After a virus enters the cell, it reverse-transcribes its genome, which is …