Glycine is a non-essential amino acid with many functions and effects. Glycine can bind to
specific receptors and transporters that are expressed in many types of cells throughout an …

Neurotransmitter transporters (NTTs) are involved in the fine-tuning of brain neurotransmitter
homeostasis. As such, they are implicated in a plethora of complex behaviors, including …

Clearance of serotonin (5-hydroxytryptamine, 5-HT) from the synaptic cleft after neuronal
signaling is mediated by serotonin transporter (SERT), which couples this process to the …

Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …

Orphan solute carrier (SLC) represents a group of membrane transporters whose exact
functions and substrate specificities are not known. Elucidating the function and regulation of …

Abstract Glycine transporter 1 (GlyT1) mediates the termination of inhibitory glycinergic
receptor signaling in the spinal cord and brainstem, and is also present diffusely in the …

Kinetic models have been employed to understand the logic of substrate transport through
transporters of the Solute Carrier (SLC) family. All SLC transporters operate according to the …

Creatine serves as an ATP buffer and is thus an integral component of cellular energy
metabolism. Most cells maintain their creatine levels via uptake by the creatine transporter …

SLC6A14 (solute carrier family 6 member 14) is an amino acid transporter, driven by Na+
and Cl− co-transport, whose structure, function, and molecular and kinetic mechanism have …

The diversity in solute carriers arose from evolutionary pressure. Here, we surmised that the
adaptive search for optimizing the rate of substrate translocation was also shaped by the …