Pathophysiology of COVID-19-associated acute kidney injury
Although respiratory failure and hypoxaemia are the main manifestations of COVID-19,
kidney involvement is also common. Available evidence supports a number of potential …
kidney involvement is also common. Available evidence supports a number of potential …
[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …
[HTML][HTML] Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment
S Peerapornratana, CL Manrique-Caballero… - Kidney international, 2019 - Elsevier
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …
Global epidemiology and outcomes of acute kidney injury
Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …
aetiologies and pathophysiological processes leading to decreased kidney function. In …
[HTML][HTML] Timing of renal-replacement therapy in patients with acute kidney injury and sepsis
SD Barbar, R Clere-Jehl, A Bourredjem… - … England Journal of …, 2018 - Mass Medical Soc
Background Acute kidney injury is the most frequent complication in patients with septic
shock and is an independent risk factor for death. Although renal-replacement therapy is the …
shock and is an independent risk factor for death. Although renal-replacement therapy is the …
Machine learning for the prediction of acute kidney injury in patients with sepsis
S Yue, S Li, X Huang, J Liu, X Hou, Y Zhao… - Journal of translational …, 2022 - Springer
Background Acute kidney injury (AKI) is the most common and serious complication of
sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is …
sepsis, accompanied by high mortality and disease burden. The early prediction of AKI is …
Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury
Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …
Sepsis-associated acute kidney injury
CL Manrique-Caballero… - Critical Care …, 2021 - criticalcare.theclinics.com
Sepsis-associated acute kidney injury (S-AKI) is a common, life-threatening complication in
hospitalized and critically ill patients. S-AKI increases in-hospital mortality 6-fold to 8-fold, 1 …
hospitalized and critically ill patients. S-AKI increases in-hospital mortality 6-fold to 8-fold, 1 …
[HTML][HTML] Focus: Death: Organ dysfunction in sepsis: An ominous trajectory from infection to death
Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
manifestations that makes it difficult to detect and treat. It is also one of the major and most …
PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
S An, Y Yao, H Hu, J Wu, J Li, L Li, J Wu, M Sun… - Cell Death & …, 2023 - nature.com
The increase of lactate is an independent risk factor for patients with sepsis-induced acute
kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its …
kidney injury (SAKI). However, whether elevated lactate directly promotes SAKI and its …