Type 2 diabetes mellitus
RA DeFronzo, E Ferrannini, L Groop… - Nature reviews Disease …, 2015 - nature.com
Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …
Regulation of hepatic glucose metabolism in health and disease
The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …
during fasting and stores glucose postprandially. However, these hepatic processes are …
Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
Insulin and insulin resistance in Alzheimer's disease
A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …
Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes
Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD)
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of …
The cell biology of systemic insulin function
Insulin is the paramount anabolic hormone, promoting carbon energy deposition in the
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …
body. Its synthesis, quality control, delivery, and action are exquisitely regulated by highly …
Obesity I: Overview and molecular and biochemical mechanisms
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …
has increased globally since the 1970s, and the number of obese and overweight people is …
Cognitive aging and the promise of physical activity
Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …
to emphasize the hope of preservation and enhancement of cognitive function in late life? A …
Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
[HTML][HTML] Insulin action at a molecular level–100 years of progress
The discovery of insulin 100 years ago and its application to the treatment of human disease
in the years since have marked a major turning point in the history of medicine. The …
in the years since have marked a major turning point in the history of medicine. The …