Background Amoxicillin has been in use since the 1970s; it is the most widely used penicillin
both alone and in combination with the β-lactamase clavulanic acid. Objectives In this …

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …

Importance The optimal dose and duration of oral amoxicillin for children with community-
acquired pneumonia (CAP) are unclear. Objective To determine whether lower-dose …

Background The appropriate duration of postoperative antibiotics for complex appendicitis is
unclear. The increasing global threat of antimicrobial resistance warrants restrictive …

Importance Short-course antibiotic therapy could enhance adherence and reduce adverse
drug effects and costs. However, based on sparse evidence, most guidelines recommend a …

SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

Background Guidance on the recommended durations of antibiotic therapy, the use of oral
antibiotic therapy, and the need for repeat blood cultures remain incomplete for gram …

A recommended first-line acute bacterial rhinosinusitis (ABR) treatment regimen includes a
high dose of orally administered amoxicillin, despite its frequent systemic adverse reactions …

Enterobacteriaceae bloodstream infections (EB-BSIs) are a common manifestation of Gram-
negative sepsis and are initially managed with empirical intravenous antibiotics. Upon …

Bariatric surgery, which is an effective treatment for obesity, and gastrectomy, which is the
primary treatment method for gastric cancer, alter the anatomy and physiology of the …