The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Epigenome reprogramming after fertilization enables transcriptionally quiescent maternal
and paternal chromatin to acquire a permissive state for subsequent zygotic genome …

In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …

Early embryonic development is driven exclusively by maternal gene products deposited
into the oocyte. Although critical in establishing early developmental programs, maternal …

Upon fertilization, embryos undergo chromatin reprogramming and genome activation;
however, the mechanisms that regulate these processes are poorly understood. Here, we …

The maternal-to-zygotic transition (MZT) is a key developmental process in metazoan
embryos that involves the activation of zygotic transcription (ZGA) and degradation of …

It is essential for cells to control which genes are transcribed into RNA. In eukaryotes, two
major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and …

Nuclear pore complexes (NPCs) are channels for nucleocytoplasmic transport of proteins
and RNAs. However, it remains unclear whether composition, structure, and permeability of …

Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …