Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

The microbial metabolite butyrate serves as a link between the intestinal microbiome and
epithelium. The monocarboxylate transporters MCT1 and SMCT1 are the predominant …

Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a
genetic and multifactorial disease, influenced by the host and environmental factors. It has …

Over the last two decades our understanding of the gut microbiota and its contribution to
health and disease has been transformed. Among a new 'generation'of potentially beneficial …

Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Colorectal cancer (CRC) accounts for about 10% of all new cancer cases globally. Located
at close proximity to the colorectal epithelium, the gut microbiota comprises a large …