Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
The next generation blueprint of computational toxicology at the US Environmental Protection Agency
RS Thomas, T Bahadori, TJ Buckley… - Toxicological …, 2019 - academic.oup.com
Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
K Paul Friedman, M Gagne, LH Loo… - Toxicological …, 2020 - academic.oup.com
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …
potential to accelerate the pace of human health safety evaluation by informing screening …
Machine learning and artificial intelligence in physiologically based pharmacokinetic modeling
Physiologically based pharmacokinetic (PBPK) models are useful tools in drug development
and risk assessment of environmental chemicals. PBPK model development requires the …
and risk assessment of environmental chemicals. PBPK model development requires the …
[LLIBRE][B] Bioanalytical tools in water quality assessment
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …
The field has exploded since and the second edition updates and reviews the application of …
Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics
Prioritizing the risk posed by thousands of chemicals potentially present in the environment
requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable …
requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable …
Toxicity profiling of flame retardants in zebrafish embryos using a battery of assays for developmental toxicity, neurotoxicity, cardiotoxicity and hepatotoxicity toward …
A Alzualde, M Behl, NS Sipes, JH Hsieh, A Alday… - Neurotoxicology and …, 2018 - Elsevier
Following the voluntary phase-out of brominated flame retardants (BFRs) due to their
environmental persistence and toxicity, the organophosphorus flame retardants (OPFRs) are …
environmental persistence and toxicity, the organophosphorus flame retardants (OPFRs) are …
High-throughput PBTK models for in vitro to in vivo extrapolation
Introduction Toxicity data are unavailable for many thousands of chemicals in commerce
and the environment. Therefore, risk assessors need to rapidly screen these chemicals for …
and the environment. Therefore, risk assessors need to rapidly screen these chemicals for …
Addressing urgent questions for PFAS in the 21st century
Despite decades of research on per-and polyfluoroalkyl substances (PFAS), fundamental
obstacles remain to addressing worldwide contamination by these chemicals and their …
obstacles remain to addressing worldwide contamination by these chemicals and their …