Control of cell death and mitochondrial fission by ERK 1/2 MAP kinase signalling
The ERK 1/2 signalling pathway is best known for its role in connecting activated growth
factor receptors to changes in gene expression due to activated ERK 1/2 entering the …
factor receptors to changes in gene expression due to activated ERK 1/2 entering the …
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops.
Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway …
Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway …
BCL2L10 is overexpressed in melanoma downstream of STAT3 and promotes cisplatin and ABT-737 resistance
MJ Quezada, ME Picco, MB Villanueva, MV Castro… - Cancers, 2020 - mdpi.com
Simple Summary BCL2L10 is the sixth and less studied protein from the group of Bcl-2 anti-
apoptotic proteins. These proteins are important therapeutic targets since they convey …
apoptotic proteins. These proteins are important therapeutic targets since they convey …
[HTML][HTML] Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis
H Guan, L **e, T Wirth, A Ushmorov - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Although Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma
(cHL) derived from germinal or post germinal B cells, they have lost the B cell phenotype in …
(cHL) derived from germinal or post germinal B cells, they have lost the B cell phenotype in …
[PDF][PDF] BCL2L10 Is Overexpressed in Melanoma Downstream of STAT3 and Promotes Cisplatin and ABT-737 Resistance. Cancers 2021, 13, 78
MJ Quezada, ME Picco, MB Villanueva… - Advances and Novel …, 2020 - core.ac.uk
The anti-apoptotic proteins from the Bcl-2 family are important therapeutic targets since they
convey resistance to anticancer regimens. Despite the suspected functional redundancy …
convey resistance to anticancer regimens. Despite the suspected functional redundancy …
Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
EJ Minihane - 2020 - repository.cam.ac.uk
Abstract The RAS-RAF-MEK1/2-ERK1/2 signalling pathway is one of the most frequently
deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly …
deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly …
內質網壓力促進 BIK 泛素化機制及其治療上的應用
黃敏瑜 - 2018 - tdr.lib.ntu.edu.tw
BIK (Bcl2-interacting killer) 屬於Bcl2 家族中BH3-only 的促進細胞凋亡蛋白. BIK
藉由跟抑制細胞凋亡蛋白包括Bcl-2, Bcl-xL 和Mcl-1 相互作用進而促使細胞走向細胞凋亡 …
藉由跟抑制細胞凋亡蛋白包括Bcl-2, Bcl-xL 和Mcl-1 相互作用進而促使細胞走向細胞凋亡 …