Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …

The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is
expressed at high levels during embryonic development and tumor progression and is …

Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease
(NAFLD), is becoming a common chronic liver disease with the characteristics of steatosis …

Recognition of neoplastic metabolic reprogramming as one of cancer's hallmarks has paved
the way for develo** novel metabolism-targeted therapeutic approaches. The use of plant …

Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2
isoform of pyruvate kinase (PKM2) was reported to have an important role in cell …

Rewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common
signature of cancer cells to meet their high energetic and biosynthetic demands of rapid …

Background: Shikonin, a small molecule inhibitor of pyruvate kinase 2 (PKM2), has been
demonstrated to play the antitumor effect in various cancers. However, the specific effects …

Understanding of the microRNAs (miRNAs) regulatory system has become indispensable
for physiological/oncological research. Tissue and organ specificities are key features of …

The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate
and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a …

Objective: The role of glycolytic enzyme PKM2 (pyruvate kinase muscle 2) in smooth muscle
cell (SMC) phenotype switching and neointimal hyperplasia is poorly understood. We …