PKM2, function and expression and regulation
Z Zhang, X Deng, Y Liu, Y Liu, L Sun, F Chen - Cell & bioscience, 2019 - Springer
Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …
subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly …
The role of PKM2 in the regulation of mitochondrial function: Focus on mitochondrial metabolism, oxidative stress, dynamic, and apoptosis. PKM2 in mitochondrial …
J Gao, Y Zhao, T Li, X Gan, H Yu - Oxidative medicine and …, 2022 - Wiley Online Library
The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is
expressed at high levels during embryonic development and tumor progression and is …
expressed at high levels during embryonic development and tumor progression and is …
[HTML][HTML] Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH
Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease
(NAFLD), is becoming a common chronic liver disease with the characteristics of steatosis …
(NAFLD), is becoming a common chronic liver disease with the characteristics of steatosis …
Targeting tumor metabolism with plant-derived natural products: Emerging trends in cancer therapy
Recognition of neoplastic metabolic reprogramming as one of cancer's hallmarks has paved
the way for develo** novel metabolism-targeted therapeutic approaches. The use of plant …
the way for develo** novel metabolism-targeted therapeutic approaches. The use of plant …
[HTML][HTML] Shikonin inhibits tumor growth of ESCC by suppressing PKM2 mediated aerobic glycolysis and STAT3 phosphorylation
Q Zhang, Q Liu, S Zheng, T Liu, L Yang, X Han… - Journal of …, 2021 - ncbi.nlm.nih.gov
Background: Shikonin, a small molecule inhibitor of pyruvate kinase 2 (PKM2), has been
demonstrated to play the antitumor effect in various cancers. However, the specific effects …
demonstrated to play the antitumor effect in various cancers. However, the specific effects …
PTBP1‐targeting microRNAs regulate cancer‐specific energy metabolism through the modulation of PKM1/M2 splicing
K Taniguchi, K Uchiyama, Y Akao - Cancer science, 2021 - Wiley Online Library
Understanding of the microRNAs (miRNAs) regulatory system has become indispensable
for physiological/oncological research. Tissue and organ specificities are key features of …
for physiological/oncological research. Tissue and organ specificities are key features of …
Pyruvate kinase M2: a multifarious enzyme in non-canonical localization to promote cancer progression
S Amin, P Yang, Z Li - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
Rewiring glucose metabolism, termed as Warburg effect or aerobic glycolysis, is a common
signature of cancer cells to meet their high energetic and biosynthetic demands of rapid …
signature of cancer cells to meet their high energetic and biosynthetic demands of rapid …
Pyruvate kinase M2 mediates glycolysis contributes to psoriasis by promoting keratinocyte proliferation
Y Liu, M Xu, X Dai, L Yan, L Li, R Zhu, L Ren… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2
isoform of pyruvate kinase (PKM2) was reported to have an important role in cell …
isoform of pyruvate kinase (PKM2) was reported to have an important role in cell …
Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment
Y Zhou, Z Huang, J Su, J Li, S Zhao… - … journal of cancer, 2020 - Wiley Online Library
The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate
and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a …
and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a …
[HTML][HTML] Pyruvate kinase M2 regulates fibrosis development and progression by controlling glycine auxotrophy in myofibroblasts
Rationale: Fibrosis is a pathologic condition of abnormal accumulation of collagen fibrils.
Collagen is a major extracellular matrix (ECM) protein synthesized and secreted by …
Collagen is a major extracellular matrix (ECM) protein synthesized and secreted by …