Methamphetamine-induced neuronal damage: neurotoxicity and neuroinflammation

B Kim, J Yun, B Park - Biomolecules & therapeutics, 2020 - pmc.ncbi.nlm.nih.gov
Methamphetamine (METH) is a highly addictive psychostimulant and one of the most widely
abused drugs worldwide. The continuous use of METH eventually leads to drug addiction …

The transcription factor Zif268/Egr1, brain plasticity, and memory

A Veyrac, A Besnard, J Caboche, S Davis… - Progress in molecular …, 2014 - Elsevier
The capacity to remember our past experiences and organize our future draws on a number
of cognitive processes that allow our brain to form and store neural representations that can …

Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction

FC Cruz, FJ Rubio, BT Hope - Brain research, 2015 - Elsevier
Learned associations between drugs and environment play an important role in addiction
and are thought to be encoded within specific patterns of sparsely distributed neurons called …

Animal models of post-traumatic stress disorder and recent neurobiological insights

AM Whitaker, NW Gilpin, S Edwards - Behavioural pharmacology, 2014 - journals.lww.com
Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder characterized by the
intrusive re-experiencing of past trauma, avoidant behavior, enhanced fear, and …

Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse

MC Allichon, V Ortiz, P Pousinha… - Frontiers in synaptic …, 2021 - frontiersin.org
Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …

Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/snail signaling pathway

YL Hsu, MF Hou, PL Kuo, YF Huang, EM Tsai - Oncogene, 2013 - nature.com
The skeleton is the most common metastatic site for breast cancer, with bone metastasis
causing pain as well as risk of pathological fractures. Interaction between tumors and the …

Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse

E Cahill, M Salery, P Vanhoutte… - Frontiers in …, 2014 - frontiersin.org
Despite their distinct targets, all addictive drugs commonly abused by humans evoke
increases in dopamine (DA) concentration within the striatum. The main DA Guanine …

[HTML][HTML] RGS14 regulation of post-synaptic signaling and spine plasticity in brain

NH Harbin, SN Bramlett, C Montanez-Miranda… - International Journal of …, 2021 - mdpi.com
The regulator of G-protein signaling 14 (RGS14) is a multifunctional signaling protein that
regulates post synaptic plasticity in neurons. RGS14 is expressed in the brain regions …

Molecular mechanism: ERK signaling, drug addiction, and behavioral effects

WL Sun, PM Quizon, J Zhu - … in molecular biology and translational science, 2016 - Elsevier
Addiction to psychostimulants has been considered as a chronic psychiatric disorder
characterized by craving and compulsive drug seeking and use. Over the past two decades …

The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens

DY Sakae, F Marti, S Lecca, F Vorspan… - Molecular …, 2015 - nature.com
Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are
centrally involved in reward behavior. TANs express a vesicular glutamate transporter …