Alzheimer's disease: treatment strategies and their limitations
Alzheimer's disease (AD) is the most frequent case of neurodegenerative disease and is
becoming a major public health problem all over the world. Many therapeutic strategies …
becoming a major public health problem all over the world. Many therapeutic strategies …
Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
F Fanizza, M Campanile, G Forloni… - Journal of Tissue …, 2022 - journals.sagepub.com
The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs
development pipeline by mimicking the physiological environment and functions of human …
development pipeline by mimicking the physiological environment and functions of human …
Harnessing cerebral organoids for Alzheimer's disease research
A Bubnys, LH Tsai - Current opinion in neurobiology, 2022 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting the aging
population. Despite many studies, there remains an urgent need to identify the root causes …
population. Despite many studies, there remains an urgent need to identify the root causes …
Effects of amyloid-β-mimicking peptide hydrogel matrix on neuronal progenitor cell phenotype
Self-assembling peptide-based hydrogels have become a highly attractive scaffold for three-
dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices …
dimensional (3D) in vitro disease modeling as they provide a way to create tunable matrices …
Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …
caused by the interaction of genetic, environmental, and familial factors. These diseases …
Current progress of cerebral organoids for modeling Alzheimer's disease origins and mechanisms
Alzheimer's disease (AD) is a progressive, neurodegenerative disease that has emerged as
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …
a leading risk factor for dementia associated with increasing age. Two‐dimensional (2D) cell …
Neuronal Dynamics and miRNA Signaling Differ between SH-SY5Y APPSwe and PSEN1 Mutant iPSC-Derived AD Models upon Modulation with miR-124 Mimic …
Neuronal miRNA dysregulation may have a role in the pathophysiology of Alzheimer's
disease (AD). miRNA (miR)-124 is largely abundant and a critical player in many neuronal …
disease (AD). miRNA (miR)-124 is largely abundant and a critical player in many neuronal …
Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease
MA Hernández-Sapiéns… - Neural Regeneration …, 2022 - journals.lww.com
The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset
familial Alzheimer's disease, harboring~ 300 causative mutations, and representing~ 90% of …
familial Alzheimer's disease, harboring~ 300 causative mutations, and representing~ 90% of …
Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome
L Kumar - Journal of Controlled Release, 2021 - Elsevier
To date, although the microscopic alterations present in Alzheimer's disease (AD) have
been well known for over a century only a handful of symptomatic treatments have been …
been well known for over a century only a handful of symptomatic treatments have been …
BACE1 inhibitors: A promising therapeutic approach for the management of Alzheimer's disease
Alzheimer's disease is a neurological disorder marked by the accumulation of amyloid beta
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …
(Aβ) aggregates, resulting from mutations in the amyloid precursor protein. The enzyme β …