Immune system dysregulation during spaceflight: potential countermeasures for deep space exploration missions
BE Crucian, A Choukèr, RJ Simpson, S Mehta… - Frontiers in …, 2018 - frontiersin.org
Recent studies have established that dysregulation of the human immune system and the
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …
reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight …
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?
N Guéguinou, C Huin-Schohn… - Journal of leukocyte …, 2009 - academic.oup.com
Review describes hazards present as humans explore space and focuses on the effects of
spaceflight on immunity. This year, we celebrate the 40th birthday of the first landing of …
spaceflight on immunity. This year, we celebrate the 40th birthday of the first landing of …
Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity
P Jacob, C Oertlin, B Baselet, LS Westerberg… - npj …, 2023 - nature.com
Although we have sent humans into space for more than 50 years, crucial questions
regarding immune response in space conditions remain unanswered. There are many …
regarding immune response in space conditions remain unanswered. There are many …
Towards human exploration of space: The THESEUS review series on immunology research priorities
JP Frippiat, BE Crucian, DJ De Quervain, D Grimm… - NPJ …, 2016 - nature.com
Dysregulation of the immune system occurs during spaceflight and may represent a crew
health risk during exploration missions because astronauts are challenged by many …
health risk during exploration missions because astronauts are challenged by many …
B-cell homeostasis is maintained during two months of head-down tilt bed rest with or without antioxidant supplementation
J Bonnefoy, B Baselet, D Moser, S Ghislin… - Frontiers in …, 2022 - frontiersin.org
Alterations of the immune system could seriously impair the ability to combat infections
during future long-duration space missions. However, little is known about the effects of …
during future long-duration space missions. However, little is known about the effects of …
Plasticity of the human IgM repertoire in response to long‐term spaceflight
JI Buchheim, S Ghislin, N Ouzren… - The FASEB …, 2020 - Wiley Online Library
Immune dysregulation is among the main adverse outcomes of spaceflight. Despite the
crucial role of the antibody repertoire in host protection, the effects of spaceflight on the …
crucial role of the antibody repertoire in host protection, the effects of spaceflight on the …
Impact of Microgravity on Virulence, Antibiotic Resistance and Gene Expression in Beneficial and Pathogenic Microorganisms
M Salavatifar, SM Ahmadi, SD Todorov… - Mini Reviews in …, 2023 - ingentaconnect.com
During space missions, the impact of the space conditions (both microgravity and radiation)
on physiologic and metabolic aspects of the microbiota of astronauts' bodies should be …
on physiologic and metabolic aspects of the microbiota of astronauts' bodies should be …
Analysis of femurs from mice embarked on board BION‐M1 biosatellite reveals a decrease in immune cell development, including B cells, after 1 wk of recovery on …
Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight
challenging astronauts' health and safety. However, consequences on B‐cell development …
challenging astronauts' health and safety. However, consequences on B‐cell development …
B cell homeostasis is maintained during long-duration spaceflight
G Spielmann, N Agha, H Kunz… - Journal of applied …, 2019 - journals.physiology.org
Long-duration spaceflights reportedly induce immune dysregulation, which is considered a
risk to astronaut safety and mission success. Recent studies have examined the impact of …
risk to astronaut safety and mission success. Recent studies have examined the impact of …
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging
C Lescale, V Schenten, D Djeghloul… - The FASEB …, 2015 - Wiley Online Library
Within the bone marrow, the endosteal niche plays a crucial role in B‐cell differentiation.
Because spaceflight is associated with osteoporosis, we investigated whether changes in …
Because spaceflight is associated with osteoporosis, we investigated whether changes in …