Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

Metformin is a first-line therapeutic option for the treatment of type 2 diabetes, even though
its underlying mechanisms of action are relatively unclear,,,,,. Metformin lowers blood …

Obesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2
diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase …

The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia caused
by resistance to insulin action, inadequate insulin secretion, or excessive glucagon …

The AMP-activated protein kinase (AMPK) system is a key player in regulating energy
balance at both the cellular and whole-body levels, placing it at centre stage in studies of …

All living organisms depend on dynamic mechanisms that repeatedly reassess the status of
amassed energy, in order to adapt energy supply to demand. The AMP-activated protein …

The LKB1→ AMPK cascade is switched on by metabolic stresses that either inhibit ATP
production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption (eg muscle …