Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including …

Skin aging is a complex process influenced by intrinsic and extrinsic factors. Together, these
factors affect the structure and function of the epidermis and dermis. Histologically, aging …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

There is increasing evidence that skin aging is significantly enforced by the accumulation of
senescent dermal fibroblasts. Various stressors damaging macromolecules inside and …

RA is the most common chronic systemic autoimmune disease, with a higher prevalence in
women, suggesting female hormonal factors play a role in the development of the disease …

Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass
and microarchitecture, which compromises bone strength. It is a complex multifactorial …

After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Obese postmenopausal women have an increased breast cancer risk, the principal
mechanism for which is elevated estrogen production by adipose tissue; also, regardless of …

We report herein a novel mechanism, unraveled by proteomics and validated by in vitro and
in vivo studies, of the aberrant aging-associated upregulation of ovarian transferrin and …

Anti-inflammatory modalities are commonly used for the treatment of various
musculoskeletal injuries. Although inflammation was originally believed to interfere with …