Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Since the time of their introduction, optical tweezers (OTs) have grown to be a powerful tool
in the hands of biologists. OTs use highly focused laser light to guide, manipulate, or sort …

Demonstration of the light radiation pressure on a microscopic level by A. Ashkin led to the
invention of optical tweezers (OT). Applied in the studies of living systems, OT have become …

Cellular and tissue biosystems emerge from the assembly of their constituent molecules and
obtain a set of specific material properties. To measure these properties and understand …

The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

The blood-brain barrier (BBB) poses a serious impediment to the delivery of effective
therapies to the central nervous system (CNS). Over time, various model systems have been …

Cancer progression to metastatic dissemination is responsible for∼ 90% of deaths in
patients. Tremendous efforts have been made to understand primary tumor growth, cancer …

This article reviews the autonomous manipulation strategies of biological cells utilizing
optical tweezers, mainly including optical direct and indirect manipulation strategies. The …

Mechanical forces are central to how cancer treatments such as chemotherapeutics and
immunotherapies interact with cells and tissues. At the simplest level, electrostatic forces …