The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex
multi-cellular organ that intimately links with the cardiovascular system to accomplish gas …

Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe
acute respiratory syndrome coronavirus 2, which predominantly affects the lungs and, under …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model …

Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …

Stem cells undergo dynamic changes in response to injury to regenerate lost cells.
However, the identity of transitional states and the mechanisms that drive their trajectories …

Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Alveolar epithelium plays a pivotal role in protecting the lungs from inhaled infectious
agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery …

Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …

Impaired differentiation of alveolar stem cells has been identified in a variety of acute and
chronic lung diseases. In this study, we investigate the mechanisms that modulate alveolar …

Lgr5+ intestinal stem cells (ISCs) depend on niche factors for their proper function. However,
the source of these ISC niche factors and how they support ISCs in vivo remain …