Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Like all sessile organisms, surface-attached communities of bacteria known as biofilms must
release and disperse cells into the environment to colonize new sites. For many pathogenic …

Cell-to-cell communication is a major process that allows bacteria to sense and coordinately
react to the fluctuating conditions of the surrounding environment. In several pathogens, this …

Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface
structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis …

Since its initial discovery as an allosteric factor regulating cellulose biosynthesis in
Gluconacetobacter xylinus, the list of functional outputs regulated by c-di-GMP has grown …

For an organism to survive, it must be able to sense its environment and regulate
physiological processes accordingly. Understanding how bacteria integrate signals from …

In the present review, we describe and compare the molecular mechanisms that are
involved in the regulation of biofilm formation by P seudomonas putida, P seudomonas …

Cyclic di-GMP (c-di-GMP) synthetases and hydrolases (GGDEF, EAL, and HD-GYP
domains) can be readily identified in bacterial genome sequences by using standard …

The cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular
physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the …

Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …