The P2X7 receptor
R Sluyter - Protein Reviews: Volume 19, 2017 - Springer
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …
triphosphate. The receptor is present on an increasing number of different cells types …
[HTML][HTML] Pharmacology of pannexin channels
M Koval, WJ Schug, BE Isakson - Current opinion in pharmacology, 2023 - Elsevier
Pannexin channels play fundamental roles in regulating inflammation and have been
implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the …
implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the …
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors
PJ Sáez, P Vargas, KF Shoji, PA Harcha… - Science …, 2017 - science.org
Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …
P2X4 and P2X7 are essential players in basal T cell activity and Ca2+ signaling milliseconds after T cell activation
VJ Brock, IMA Wolf, M Er-Lukowiak, N Lory… - Science …, 2022 - science.org
Initial T cell activation is triggered by the formation of highly dynamic, spatiotemporally
restricted Ca2+ microdomains. Purinergic signaling is known to be involved in Ca2+ influx in …
restricted Ca2+ microdomains. Purinergic signaling is known to be involved in Ca2+ influx in …
P2X7 on mouse T cells: one channel, many functions
The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is
expressed by several cells of the immune system. P2X7 is best known for its …
expressed by several cells of the immune system. P2X7 is best known for its …
Pannexin biology and emerging linkages to cancer
Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …
Pathological ATPergic signaling in major depression and bipolar disorder
P Illes, A Verkhratsky, Y Tang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
The mood disorders, major depression (MD) and bipolar disorder (BD), have a high lifetime
prevalence in the human population and accordingly generate huge costs for health care …
prevalence in the human population and accordingly generate huge costs for health care …
Mechanisms of connexin regulating peptides
Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
Emerging role of P2X7 receptors in CNS health and disease
Purinergic signalling in the brain is becoming an important focus in the study of CNS health
and disease. Various purinergic receptors are found to be present in different brain cells in …
and disease. Various purinergic receptors are found to be present in different brain cells in …
[HTML][HTML] Determination of structural features that underpin the pannexin1 channel inhibitory activity of the peptide 10Panx1
A Caufriez, A Lamouroux, C Martin, D Iaculli… - Bioorganic …, 2023 - Elsevier
Pannexin1 channels facilitate paracrine communication and are involved in a broad
spectrum of diseases. Attempts to find appropriate pannexin1 channel inhibitors that …
spectrum of diseases. Attempts to find appropriate pannexin1 channel inhibitors that …