Role of oxidative modifications in atherosclerosis
R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …
Genetically modified porcine-to-human cardiac xenotransplantation
A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial
extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard …
extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard …
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress.
The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this …
The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this …
Mechanisms of cell protection by heme oxygenase-1
Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …
Mechanisms of cell death in oxidative stress
SW Ryter, HP Kim, A Hoetzel, JW Park… - Antioxidants & redox …, 2007 - liebertpub.com
Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …
environmental stress have long been implicated in tissue injury in the context of a variety of …
Heme oxygenase-1: unleashing the protective properties of heme
Abstract Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide
(CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the …
(CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the …
Delayed graft function in kidney transplantation
Delayed graft function is a form of acute renal failure resulting in post-transplantation
oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and …
oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and …
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now
show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by …
show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by …
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
R Motterlini, R Foresti, R Bassi, CJ Green - Free Radical Biology and …, 2000 - Elsevier
Curcumin, a widely used spice and coloring agent in food, has been shown to possess
potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo …
potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo …