Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals

RF Hillary, DL McCartney, HM Smith, E Bernabeu… - PLoS …, 2023 - journals.plos.org
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

Chronic pain epidemiology and its clinical relevance

O Van Hecke, N Torrance… - British journal of …, 2013 - academic.oup.com
Chronic pain affects∼ 20% of the European population and is commoner in women, older
people, and with relative deprivation. Its management in the community remains generally …

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

A Okbay, Y Wu, N Wang, H Jayashankar, M Bennett… - Nature …, 2022 - nature.com
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

LJ Howe, MG Nivard, TT Morris, AF Hansen… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

GDF15 linked to maternal risk of nausea and vomiting during pregnancy

M Fejzo, N Rocha, I Cimino, SM Lockhart, CJ Petry… - Nature, 2024 - nature.com
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …

Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records

EJ Thompson, DM Williams, AJ Walker… - Nature …, 2022 - nature.com
The frequency of, and risk factors for, long COVID are unclear among community-based
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …

Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

W Zhou, M Kanai, KHH Wu, H Rasheed, K Tsuo… - Cell genomics, 2022 - cell.com
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Genetic mechanisms of critical illness in COVID-19

E Pairo-Castineira, S Clohisey, L Klaric, AD Bretherick… - Nature, 2021 - nature.com
Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Psychological distress before and during the COVID-19 pandemic among adults in the United Kingdom based on coordinated analyses of 11 longitudinal studies

K Patel, E Robertson, ASF Kwong, GJ Griffith… - JAMA Network …, 2022 - jamanetwork.com
Importance How population mental health has evolved across the COVID-19 pandemic
under varied lockdown measures is poorly understood, and the consequences for health …

Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts

ASF Kwong, RM Pearson, MJ Adams… - The British journal of …, 2021 - cambridge.org
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …