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Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
Chronic pain epidemiology and its clinical relevance
O Van Hecke, N Torrance… - British journal of …, 2013 - academic.oup.com
Chronic pain affects∼ 20% of the European population and is commoner in women, older
people, and with relative deprivation. Its management in the community remains generally …
people, and with relative deprivation. Its management in the community remains generally …
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …
effects of inherited variation (direct effects), demography (population stratification …
GDF15 linked to maternal risk of nausea and vomiting during pregnancy
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full …
Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records
The frequency of, and risk factors for, long COVID are unclear among community-based
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …
individuals with a history of COVID-19. To elucidate the burden and possible causes of long …
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …
genomic loci across a range of human diseases and traits. However, most biobanks are …
Genetic mechanisms of critical illness in COVID-19
Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …
Psychological distress before and during the COVID-19 pandemic among adults in the United Kingdom based on coordinated analyses of 11 longitudinal studies
Importance How population mental health has evolved across the COVID-19 pandemic
under varied lockdown measures is poorly understood, and the consequences for health …
under varied lockdown measures is poorly understood, and the consequences for health …
Mental health before and during the COVID-19 pandemic in two longitudinal UK population cohorts
BackgroundThe COVID-19 pandemic and mitigation measures are likely to have a marked
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …
effect on mental health. It is important to use longitudinal data to improve inferences. AimsTo …