Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Growth rates made easy
Abstract In the 1960s–1980s, determination of bacterial growth rates was an important tool
in microbial genetics, biochemistry, molecular biology, and microbial physiology. The …
in microbial genetics, biochemistry, molecular biology, and microbial physiology. The …
A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species
Currently available tools for multiplex bacterial genome engineering are optimized for a few
laboratory model strains, demand extensive prior modification of the host strain, and lead to …
laboratory model strains, demand extensive prior modification of the host strain, and lead to …
Comparing treatment strategies to reduce antibiotic resistance in an in vitro epidemiological setting
The rapid rise of antibiotic resistance, combined with the increasing cost and difficulties to
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …
develop new antibiotics, calls for treatment strategies that enable more sustainable antibiotic …
Mutation—the engine of evolution: studying mutation and its role in the evolution of bacteria
R Hershberg - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Mutation is the engine of evolution in that it generates the genetic variation on which the
evolutionary process depends. To understand the evolutionary process we must therefore …
evolutionary process depends. To understand the evolutionary process we must therefore …
Size is not everything: rates of genome size evolution, not C-value, correlate with speciation in angiosperms
Angiosperms represent one of the key examples of evolutionary success, and their diversity
dwarfs other land plants; this success has been linked, in part, to genome size and …
dwarfs other land plants; this success has been linked, in part, to genome size and …
Experimental demonstration of operon formation catalyzed by insertion sequence
Operons are a hallmark of the genomic and regulatory architecture of prokaryotes. However,
the mechanism by which two genes placed far apart gradually come close and form operons …
the mechanism by which two genes placed far apart gradually come close and form operons …
First-step mutations during adaptation restore the expression of hundreds of genes
The temporal change of phenotypes during the adaptive process remains largely
unexplored, as do the genetic changes that affect these phenotypic changes. Here we …
unexplored, as do the genetic changes that affect these phenotypic changes. Here we …
The adaptation of Escherichia coli cells grown in simulated microgravity for an extended period is both phenotypic and genomic
Microorganisms impact spaceflight in a variety of ways. They play a positive role in
biological systems, such as waste water treatment but can be problematic through buildups …
biological systems, such as waste water treatment but can be problematic through buildups …