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Wnt/β-catenin signaling pathway in carcinogenesis and cancer therapy
The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
encompassing development, tissue homeostasis, and cell proliferation. Under normal …
WNT as a driver and dependency in cancer
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
Regulation of tumor initiation by the mitochondrial pyruvate carrier
Although metabolic adaptations have been demonstrated to be essential for tumor cell
proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We …
proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We …
Wnt pathway regulation of intestinal stem cells
AT Mah, KS Yan, CJ Kuo - The Journal of physiology, 2016 - Wiley Online Library
Wnt signalling is involved in multiple aspects of embryonic development and adult tissue
homeostasis, notably via controlling cellular proliferation and differentiation. Wnt signalling …
homeostasis, notably via controlling cellular proliferation and differentiation. Wnt signalling …
Mouse models of intestinal cancer
Murine models of intestinal cancer are powerful tools to recapitulate human intestinal
cancer, understand its biology and test therapies. With recent developments identifying the …
cancer, understand its biology and test therapies. With recent developments identifying the …
KLF9 and JNK3 interact to suppress axon regeneration in the adult CNS
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …
Wnt signalling in gastrointestinal epithelial stem cells
Wnt signalling regulates several cellular functions including proliferation, differentiation,
apoptosis and migration, and is critical for embryonic development. Stem cells are defined …
apoptosis and migration, and is critical for embryonic development. Stem cells are defined …
Emerging understanding of multiscale tumor heterogeneity
Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and
cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer …
cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer …
Modeling the process of human tumorigenesis
Modelling the genesis of human cancers is at a scientific turning point. Starting from primary
sources of normal human cells, it is now possible to reproducibly generate several types of …
sources of normal human cells, it is now possible to reproducibly generate several types of …
WNT and β-Catenin in Cancer: Genes and Therapy
The WNT pathway is a pleiotropic signaling pathway that controls developmental processes,
tissue homeostasis, and cancer. The WNT pathway is commonly mutated in many cancers …
tissue homeostasis, and cancer. The WNT pathway is commonly mutated in many cancers …