Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …

Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …

All microorganisms are exposed to periodic stresses that inhibit growth. Many bacteria and
fungi weather these periods by entering a hardy, nonreplicating state, often termed …

Summary The ClpC1: ClpP1P2 protease is a core component of the proteostasis system in
mycobacteria. To improve the efficacy of antitubercular agents targeting the Clp protease …

Deciphering physiological changes that mediate transition of Mycobacterium tuberculosis
between replicating and nonreplicating states is essential to understanding how the …

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …

Metabolic adaptation to the host niche is a defining feature of the pathogenicity of
Mycobacterium tuberculosis (Mtb). In vitro, Mtb is able to grow on a variety of carbon …

Our understanding of bacterial pathogenesis is dominated by the cell biology of the host–
pathogen interaction. However, the majority of metabolites that are used in prokaryotic and …

Latent tuberculosis infection (LTBI) has become a major source of active tuberculosis (ATB).
Although the tuberculin skin test and interferon-gamma release assay can be used to …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …