Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

Stem cells undergo dynamic changes in response to injury to regenerate lost cells.
However, the identity of transitional states and the mechanisms that drive their trajectories …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or
mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 …

Tumor cells exhibit at least two distinct modes of migration when invading the 3D
environment. A single tumor cell's invasive strategy follows either mesenchymal or …

The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front
of a number of human carcinomas. We have investigated podoplanin function in cultured …

Tunneling nanotubes (TNTs) can be induced in rat hippocampal astrocytes and neurons
with H 2 O 2 or serum depletion. Major cytoskeletal component of TNTs is F-actin. TNTs …

Abstract The Rho family of GTPases represents a class of Ras-related signaling molecules
often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP …

Rho GTPases are involved in the acquisition of all the hallmarks of cancer, which comprise 6
biological capabilities acquired during the development of human tumors. The hallmarks …

Septins are an evolutionarily conserved group of GTP‐binding and filament‐forming
proteins that belong to the large superclass of P‐loop GTPases. While originally discovered …