The US is grappling with an opioid epidemic, with millions of adults on long-term opioid
therapy (LTOT). Although patients often report pain relief and improved daily function with …

An increasing number of studies support the utilization of acupuncture for the treatment of
fibromyalgia. Though no head-to-head comparison was able to show the superiority of …

This paper is the forty-second consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Sleep and opioid medications used to treat insomnia and chronic pain are associated with
adverse side effects (falls and cognitive disturbance). Although behavioural treatments such …

The multimorbidity formed by sleep disturbances and pain conditions is highly prevalent and
has a significant impact in global health and in the socioeconomic system. Although different …

Sedative–hypnotic misuse is associated with psychiatric diseases and overdose deaths. It
remains uncertain whether types of anesthesia affect the occurrence of new postoperative …

Fibromyalgia syndrome (FMS) is characterized by generalized chronic musculoskeletal
pain, fatigue, and sleep disturbance, as well as cognitive, somatic, and other symptoms …

Background In the past three decades, prescription opioid use has increased dramatically in
the United States (US). This has resulted in opioid addiction, increased overdose deaths …

Fibromyalgia is a clinical entity characterized by the combination of chronic widespread pain
and other non-pain symptoms, including fatigue, poor sleep, and cognitive disturbances …

Background In traditional Chinese medicine, Ligusticum chuanxiong Hort.(LCH) is used to
treat neuropathic pain (NP). This study was performed to investigate the underlying …