Liquid biopsy enters the clinic—implementation issues and future challenges
Historically, studies of disseminated tumour cells in bone marrow and circulating tumour
cells in peripheral blood have provided crucial insights into cancer biology and the …
cells in peripheral blood have provided crucial insights into cancer biology and the …
Integrating liquid biopsies into the management of cancer
During cancer progression and treatment, multiple subclonal populations of tumour cells
compete with one another, with selective pressures leading to the emergence of …
compete with one another, with selective pressures leading to the emergence of …
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
Nanotechnology in cancer diagnosis: progress, challenges and opportunities
Y Zhang, M Li, X Gao, Y Chen, T Liu - Journal of hematology & oncology, 2019 - Springer
In the fight against cancer, early detection is a key factor for successful treatment. However,
the detection of cancer in the early stage has been hindered by the intrinsic limits of …
the detection of cancer in the early stage has been hindered by the intrinsic limits of …
Challenges in circulating tumour cell research
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …
as new biomarkers and the subject of basic research. Although CTCs are already used in …
Tumor heterogeneity in breast cancer
G Turashvili, E Brogi - Frontiers in medicine, 2017 - frontiersin.org
Breast cancer is a heterogeneous disease and differs greatly among different patients
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …
(intertumor heterogeneity) and even within each individual tumor (intratumor heterogeneity) …
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the …
circulating tumor cells (CTCs) found in the blood of patients. However, although the …
Advances and applications of single-cell sequencing technologies
Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
studying rare cells and delineating complex populations. Over the past 5 years, SCS …
[HTML][HTML] Circulating tumor cell technologies
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …
Breast cancer as a systemic disease: a view of metastasis
AJ Redig, SS McAllister - Journal of internal medicine, 2013 - Wiley Online Library
Breast cancer is now the most frequently diagnosed cancer and leading cause of cancer
death in women worldwide. Strategies targeting the primary tumour have markedly …
death in women worldwide. Strategies targeting the primary tumour have markedly …