With new data about different aspects of schizophrenia being continually generated, it
becomes necessary to periodically revisit exactly what we know. Along with a need to review …

Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

The neurodevelopmental period spanning early-to-middle childhood represents a time of
significant growth and reorganisation throughout the cortex. Such changes are critical for the …

Certain clinical features of schizophrenia, such as working memory disturbances, appear to
emerge from altered gamma oscillatory activity in the prefrontal cortex (PFC). Given the …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Data from animal models and from postmortem studies suggest that schizophrenia is
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …

Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

In schizophrenia, abnormal neural metabolite concentrations may arise from cortical
damage following neuroinflammatory processes implicated in acute episodes. Inflammation …

The underlying pathologies of psychiatric disorders, which cause substantial personal and
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …

Psychomotor slowing is a frequent symptom of schizophrenia. Short-interval intracortical
inhibition assessed by transcranial magnetic stimulation demonstrated inhibitory dysfunction …